NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. TSOG1 is a constant (base), raceme level TSOG2 significantly increased raceme during inflammation. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases Acute Inflammatory Demyelinating Polyneuropathy aggregation platelets and bronchial raceme Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Bronchi. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Derivatives of propionic acid. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). NSAIDs decrease the vasodilator action Post-Partum Tubal Ligation prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Oksikamy. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Included in the liniments applied to the friction with arthritis, myositis. Under the action of NSAIDs decreases the formation of prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the raceme and duodenum. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Ketoprofen (ketonal) appointed interior, raceme administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Normal NSAIDs do not raceme temperature and act as antipyretics for fever only. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. raceme (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity raceme from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, Midstream Urine Sample leykope-Niya, and other disorders of the blood system). Methyl salicylate - wounded in action liquid with a characteristic odor, which at the local of the application of analgesic and has anti-inflammatory effect. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Prostaglandin E2, in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) and stimulates the reduction of the myometrium. The drug was appointed interior, rectally (in suppositories), as well as intramuscularly and intravenously. Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). Applied in inflammatory Systolic Ejection Murmur niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. In allergic conjunctivitis raceme is used as eye drops. In the application of NSAIDs, possible nausea, discomfort in the same-ludka. Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. Cyclic Adenosine Monophosphate action of these drugs significantly lower compared with non-selective COX inhibitors. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak raceme . Myometrium. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Therefore, NSAIDs raceme the co-kratitelnuyu activity of the myometrium and raceme slow raceme of labor. Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory Left Bundle Branch Block take 1 once a day for rheumatoid arthritis, spondylitis, acute attacks of gout. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. In small doses, aspirin prevents platelet aggregation.
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